Haunted by a malevolent spirit since childhood, a desperate mother allows herself to become possessed in order to save the life of her terminally ill daughter.
Ready to leave his profession behind, Loreno, an assassin, lends help to an old friend, Cetan, and taking one last job in Thailand seeking out a local kingpin. A lapse in judgment means Loreno crosses paths with old colleague Paul.
Following the death of their patriarch Gus, the Portokalos family travels to Greece for a family reunion, and to deliver Gus' journal to his old friends.